Protein Details: P2X purinoceptor 4
Protein ID
ICDB_Pro_0585
Protein Name
P2X purinoceptor 4
Gene Name
P2rx4
Organism
Rattus norvegicus (Rat)
Length
388 amino acids
AlphaFoldDB
AF-P51577-F1-model_v4.pdb
Function
ATP-gated nonselective transmembrane cation channel permeable to potassium; sodium and calcium. CTP; but not GTP or UTP; functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP; it plays multiple role in immunity and central nervous system physiology. Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon activation; drives microglia motility via the PI3K/Akt pathway. Could also function as an ATP-gated cation channel of lysosomal membranes.
Sequence
Ligand Binding
Binding Site
BINDING 67; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 67; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 69; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 69; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 186; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 186; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 188; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 293; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 293; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 295; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 295; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 313; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 313; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000250|UniProtKB:F8W463"
Disease
Location
Widespread distribution in the brain. Strongly expressed in microglial cells. Also expressed in epithelial cells (PubMed:8598206). Also expressed in epithelial cells (PubMed:8598206). Also expressed in epithelial cells (PubMed:8598206).
DOI ID
10.1523/jneurosci.16-02-00448.1996; 10.1016/0014-5793(95)01203-q; 10.1006/bbrc.1996.0380; 10.1002/j.1460-2075.1996.tb00333.x; 10.1073/pnas.93.8.3684; 10.1101/gr.2596504; 10.1038/nature01786; 10.1242/jcs.02451; 10.1111/j.1471-4159.2004.02939.x; 10.1021/bi401711n; 10.1074/jbc.m114.552158; 10.1016/j.febslet.2015.01.034; 10.1038/srep45208
RefSeq
NP_113782.1